A Study of Some Immunological and Hematological Aspects in Children with Renal Disease

Authors

  • Eman A. Muhsin Water and Renewable Energy Directorate, Ministry of Environment, Iraq
  • Shahrazad A. Khalaf Department of Biotechnology, College of Science, University of Diyala, Diyala, Iraq
  • Iman H. Gatea Water and Renewable Energy Directorate, Ministry of Environment, Iraq
  • Esam A. Abdalwahed Water and Renewable Energy Directorate, Ministry of Environment, Iraq

Keywords:

Cytokines, Interleukin-6, Erythropoietin, Renal disease, Renal function, Anemia

Abstract

This study was carried out between September 17, and December 25, 2023. It included 62 pediatric patients at the age range (1-12) years of both genders: 26 with chronic renal failure (CRF) and 36 with nephrotic syndrome (NS), who were outpatients and in-patients in the dialysis unit in both Al-Mansour pediatric teaching hospital and Child's central teaching hospital. The control group consisted of 26 children. Blood samples were collected from patients and controls. Immunological tests of interleukin-6 (IL-6) and erythropoietin (Epo) measurement were done by using ELISA technique. Biochemical tests, including blood urea and serum creatinine, were applied to evaluate renal function. Hematological aspects referred to anemia presence or not; by measuring PCV and Hb. The results explained significant increase in serum IL-6 levels (P<0.001), significant decrease in serum Epo levels (P<0.001), significant increase in both urea and creatinine concentrations (P<0.001) in serum and significant decrease in both PCV and Hb (P<0.001) in NS and CRF patients in comparison with the control group

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www.kidney-international.org

www.ncbi.nlm.nih.gov

Published

2024-04-09

How to Cite

Muhsin, E. A., Khalaf, S. A., Gatea, I. H., & Abdalwahed, E. A. (2024). A Study of Some Immunological and Hematological Aspects in Children with Renal Disease. Journal of Prospective Researches, 24(2), 30–36. Retrieved from https://jpr.hcu.edu.iq/index.php/Prospective_Researches_Journal/article/view/420

Issue

Vol. 24 No. 2 (2024)

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Articles

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